Food can become contaminated with chemicals at any stage of production, i.e. from the farm to the table. Some of the food contaminants include chemicals used in food production such as pesticides and veterinary drugs. Others are natural chemicals such as heavy metals, which are acquired through the food web. Other toxic chemicals are natural toxins produced by fish, mushrooms, and higher plants, or by parasitic fungi, which grow on grain products. Indeed some toxins are generated during food processing such as frying. People can be affected by any of these chemicals singly and/or in combination. In addition, people may become allergic or sensitized to certain food components. The purpose of this course is to develop an understanding of the nature and properties of toxic substances in foods and the nature and magnitude of hazards they represent to human health.
Course Objectives
Students will:
A.Gain knowledge of the scope of food toxicology
B.Gain an understanding of the basic principles of toxicology
C.Distinguish between safety, hazard and toxicity
D.Gain knowledge of toxic substances in food and their toxic effects in people
E.Develop skills necessary to critically evaluate food toxicology publications in lay and scientific literature
F.Gain an understanding of current issues in food safety toxicology
Participating Faculty
Steve Bursian
Karen Chou
Heather Erika Hallen
Wilson Rumbeiha (Course moderator)
Ewen Todd
Gangur Venugopal
Course Modules
Principles of toxicology applicable to foods and food toxicants. January08-January 21 (Wilson Rumbeiha, 2 wk, 6h). Assignment due January 29th 2007.
In this module students will learn about the terminology used in toxicology, and about absorption, distribution, metabolism and excretion of toxic chemicals. They will also learn about general mechanisms by which toxic chemicals cause disease in humans. This module is worth 12 points (10 points for assignments, 2 points for class participation.
Food allergy and hypersensitivity. January 22 - February 04. (Gangur Venugopal, 2 wks, 6 h). Assignment due February 12.
About 10% of all Americans experience allergy or hypersensitivity reactions to certain food components. Allergy is one form of toxic response. In this module, students will be introduced to the immune system, mechanisms of allergic-type reactions, and allergenic components in foods. Module is worth 12 points, 10 points for assignment, and 2 points for class participation.
Natural toxins in seafoods. February 05- February 11. (Ewen Todd, 1 week, 3h). Module is worth 6 points, 5 points for assignments, and 1 point for class participation.
Some species of fish and other marine animals accumulate toxins from their diets or make the toxins by themselves. In this module, students will learn about the effects of natural toxins in seafoods and their effects in humans. Assignment is due February 19.
Safety of biotechnology derived novel foods. February12 to February 18. (Gangur Venugopal, 1 week, 3h). Module is worth 6 points, 5 for assignment, and 1 for class participation.
The safety of genetically modified organisms (GMOs) is subject of great public interest. In this module, students will learn about how GMOs are made and explore the potential health impact in humans. Assignment is due February 26th.
Natural toxins in plant foodstuff. February 19- February 25. (Heather Erika Hallen, 1 week, 3h). Module is worth 6 points, 5 for assignments, and 1 for class participation.
Some higher plants contain natural toxins, which are harmful to humans. In this module, students will learn about these natural plant toxins and their effects in humans. Assignment is due March 5.
Natural toxins in mushrooms. February 26 to March 04. (Heather Erika Hallen, 1week, 3h). Module is worth 6 points, 5 for assignments, and 1 for class participation.
Some species of mushrooms are toxic and are mistakenly incorporated in food with disastrous consequences. The toxicity of poisonous mushrooms in humans will be discussed in this module. Assignment is due March 12. Spring Break. March 5 to March 09. No classes.
Mycotoxins. March 12 to March 25. (Wilson Rumbeiha, 2 weeks, 6 h). Module is worth12 points, 10 for assignments and 2 for class participation.
Mycotoxins, the toxic secondary metabolites of fungi, which grow on a variety of grains cause various diseases in people and animals, including cancer, immunosuppression, kidney disease etc. This module will focus on some of the most common mycotoxins and their effect on health. Assignment is due April 02.
Toxic environmental inorganic and organometallic food contaminants. March 26 to April 01. (Karen Chou, 1 wk, 3h). Module is worth 6 points, 5 for assignments and 1 for class participation.
Foods are sometimes contaminated by heavy metals. This module will explore heavy metals likely to be encountered in foodstuffs, their sources and their impact on human health. Assignment is due April 09.
Toxic man-made organic food contaminants. April 02 to April 15. (Steve Bursian, 2 weeks, 6h). This module is worth 12 points, 10 for assignments, 2 for class participation.
Environmental pollution can be a significant source of persistent organic pollutants in foodstuffs. In this module, students will learn about pesticides and other persistent organic compounds, which are important in food toxicology. Assignment is due April 23.
Term Paper. April 16 to April 29. (Students, 2 weeks). This paper is worth 20 points. It is due April 30th 2007.
Evaluation
This will consist of assignments/tests (65 points), a term paper (20 points) and class participation 13 points. A 3 h module will account for 5points on assignments/tests and 1 point for class participation (10points for assignments and 2 points for class participation for a 6 h module). Class participation will be assessed by student postings on the discussion board in both questions and comments or answers to class questions. Instructors will have the flexibility of deciding on how to assess students in their respective modules.
Assignments/tests will be posted on the first day of the module. Assignment deadlines will be strictly adhered to. Students who turn in all their assignments on time will be awarded 2 points at the end of the semester.
Term Paper Assignment (20 points)
The term paper is to be a written review based on peer-reviewed publications on a topic of current interest in the field of food toxicology. The paper should cover an in-depth review of the topic of choice. Papers should be fully documented and include references to at least five journal articles published no later than 2002. Papers should be done with 2.0 line spacing. In addition to the paper, students will be expected to make an online power presentation of their paper to the class. Power point presentations should be posted by April 30th 2007. The evaluation will take into consideration both the quality of the paper and the power point presentation (10 points for the paper, 10 points for the power point presentation). The review should provide adequate background information to introduce the reader to the topic and should be at a level appropriate for this graduate level course. The subjects/topics for the paper require prior approval from the moderator and should be selected before March 5th 2007. Students are encouraged to discuss potential topics of interest as early as the first week during the course.
A partial list of suggested general topics for the papers follows:
Membrane transports of xenobiotics
Biomarkers for toxin exposure
Mechanisms and regulations of xenobiotic metabolism
Mode of action of natural food-borne toxicants
Identification and mechanism of action of dietary anticarcinogens
Hormonally active substances in food
Diet and gene regulation associated with disease
Diet and abnormal cell development
Safety of irradiated foods
Selected seafood toxins and mechanisms of action
Food allergens and human health
Students may suggest other topics of specific interest to them. Student-initiated topics should be discussed with the course moderator to be sure that the content is at a graduate course level. Although April 30th is the deadline for the paper, papers can be turned in at anytime during the semester (encouraged).